Chondromyxoid fibroma is a type of cartilaginous tumor most cases are characterised by grm1 gene fusion or promoter swapping. Chondromyxoid fibromas cmfs are extremely rare, benign cartilaginous neoplasms that account for chondromyxoid fibroma but no cartilaginous areas, usually older adults. Chondromyxoid fibroma definition of chondromyxoid fibroma. Since 1948, when jaffe and lichtenstein first recognized this tumor as a distinct entity, and. Chondromyxoid fibroma is a benign tumor of bone that is characterized by chondroid and myxoid differentiation and by ultrastructural and immunohistochemical evidence of chondral origin. To our knowledge, this case report represents the first description of cmf involving an extragnathic site in the facial skeleton exclusive of the cranium. It has a cartilagelike matrix composed of chondroid, fibrous, and myxoid areas in varying proportions. Bullous lesions in patient with lupus explore this issuefebruary 2016 her chest radiograph revealed no. Rarer locations include the fibula, scapula, vertebrae and ribs 3.
Chondromyxoid fibroma is a rare benign tumor that usually occurs in the long bones and rarely affects the sinonasal region. Tinu syndrome with concomitant synovitis rheumatology case report. This article is from archives of plastic surgery, volume 41. Metaphysis of long tubular bones, small bones of feet or any bone, skull base clivus. It was dense on plain ct scan and showed no convincing contrast enhancement. Clinically, it is characterized by a lobular growth pattern and.
We analyzed rapid romanowsky and papanicolaoustained slides with a respect to overall cellularity, the presence of hypercellular chondromyxoid fragments hcfs, nuclear atypia, cytoplasmic features, and the presence of. Chondromyxoid fibroma cmf is a benign neoplasm accounting for fewer than 1% of all bone tumors. The possibility of chondromyxoid fibroma should always be considered when a focal bone lesion is evaluated that has geographic bone destruction, a sclerotic rim, lobulated margins, and septation. Surgical management of a giant sternal chondromyxoid. Chondromyxoid fibroma, cmf, is the least common benign cartilaginous tumor composed of chondroid and myxoid matrix. Mri of chondromyxoid fibroma article pdf available in acta radiologica 528. Less common lesions include fibrous dysplasia, fibroxanthoma nonossify ing fibroma, chondromyxoid fibroma, solitary bone cyst, fibrous histiocytoma, eosinophilic granuloma, and even osteosarcoma. Chondromyxoid fibroma of bone, a clinicopathologic study of thirtytwo cases.
In many cases, the tumor will destroy portions of the bone and aggressively grow, pushing into the surrounding soft tissues. Chondromyxoid fibroma with secondary aneurysmal bone cyst. Chondromyxoid fibroma is a type of cartilaginous tumor. Despite a characteristic radiographic appearance, chondromyxoid fibroma with atypical radiographic findings may mimic more common tumors. To present a case of chondromyxoid fibroma of the nasal bone and discuss its presentation.
Juxtacortical chondromyxoid fibroma which may be seen in unusual places such as intracortical, or sub periosteallocations is very unusual. Sep 24, 2018 chondromyxoid fibroma cmf is a rare, slowgrowing, benign bone tumor of chondroblastic derivation. It usually affects the metaphyseal region of long bones of patients in their first or second decade of life. July 27, 2017 056 the tumor may be discovered incidentally during radiography 1. It is associated with high local recurrence rates with a small risk sep 24, 2018 chondromyxoid fibroma. Chondromyxoid fibroma is a very rare benign cartilaginous tumor representing less than 0. Smaller lesions are typically located in the cortex of long bones. With contrast injection, the central portion of the lesion may show no enhancement due to the myxoid component. Chondromyxoid fibroma cmf is one of the rarest of bone tumors, accounting for less than 1% of all bone tumors. May 12, 2014 surgical excision is the firstline choice for chondromyxoid fibroma, for which only simple curettage is performed or a bone graft is used for filling the cavitary defect following curettage.
In xrays, they are often surrounded by a white sclerotic rim. Bullous lesions in patient with lupus explore this issuefebruary 2016 her chest radiograph revealed no infiltrates. Eight new cases are added, 4 of which exhibited unusual size andor focal microscopic calcification, pathologic fracture, diaphyseal location. Soni r, kapoor c, shah m, turakhiya j, golwala p 2016 chondromyxoid fibroma. Chondromyxoid fibroma cmf is a rare benign bony tumour.
The lesion is never purely epiphyseal, but may extend into the subchondral b. Chondromyxoid fibroma cmf is a rare, benign bone tumour. Chondromyxoid fibroma is a rare benign primary bone tumor of cartilage. Sep 12, 2014 chondromyxoid fibroma cmf is a rare, benign bone tumour. Sep 23, 2016 chondromyxoid fibroma cmf is a benign, locally aggressive tumor of cartilaginous origin and accounts for less than 0. Treatment for cmf requires surgery to remove the tumor. Abstract chondromyxoid fibroma is a benign, although potentially aggressive tumor, with a cartilagelike matrix, accounting for approximately 1% of all bone tumors. This is an advanced case of a benign chondromyxoid fibroma. Jan 01, 2009 chondromyxoid fibroma cmf is a rare neoplasm constituting less than 1% of all bone tumors. A primary chondromyxoid fibroma cmf arising from sternum is quite uncommon tumor in thoracic surgery. It has a predilection for men in the second and third decades of life with the metaphyseal regions of the long bones of the lower extremities as the favored sites of occurrence. It is usually located eccentrically in distal femur or proximal tibia metaphysis. A case of chondromyxoid fibroma cmf involving the zygoma is presented. Although variable depending on the reports, the recurrence is estimated at approximately 25%.
Chondromyxoid fibroma cmf is a benign, locally aggressive tumor of cartilaginous origin and accounts for less than 0. Upon history taking, we found that the mass had formed 7 to 8 years before and had since grown. Chondromyxoid fibroma may occur anywhere in the skeleton, but almost half of the cases occur around the knee. In 1948, the tumor was first described by jaffe and lichtenstein as a lesion derived from cartilageforming tissue and composed of various proportions of chondroid, fibrous, and myxoid tissues. Removal of giant sternal tumors requires extensive resection of the anterior chest wall, and results in deformity and paradoxical movement. Chondromyxoid fibroma constitutes a rare benign tumor of the bones, which has a potential of regional enlargement towards the local tissues. The diagnosis of cmf depends upon its characteristic histological appearance like a lobular pattern with stellateshaped cells. Primary chondromyxoid fibroma of the sternum is quite rare, with only six cases documented in the literature see table 1. A chondromyxoid fibroma cmf is an extremely rare benign cartilaginous neoplasm which accounts for chondromyxoid fibroma of the foot. Fineneedle aspiration biopsy of chondromyxoid fibroma.
Both clinically and histologically, it is a difficult diagnosis and can be confused with malignant lesions. It occurs most frequently in the metaphysis of long tubular bones, and an epiphyseal location is exceedingly rare. It is most commonly found in the metaphysis of long bones and usually presents in the second or third decade of life. Chondromyxoid fibroma cmf is an extremely rare, benign cartilaginous tumor that makes up 0. Pdf chondromyxoid fibroma cmf is a rare benign mesenchymal tumor of the bone. Chondromyxoid fibroma cmf is a benign tumor of cartilagenous origin and rarest of all bone tumors. Chondromyxoid fibroma of the frontal bone tatsuo morimura, 12 atsuhisa nakano, 1 tsuyoshi matsumoto, 1 and eiichi tani1 summary. Get a printable copy pdf file of the complete article 647k, or click on a page image below to browse page by page. Chondromyxoid fibroma of the finger pubmed central pmc. Fineneedle aspiration biopsy of chondromyxoid fibroma an. It is composed of a mixture of chondroid, myxoid, and fibrous tissues. Chondromyxoid fibroma is the least commonly occurring bone tumor, accounting for approximately 1% of all biopsied primary bone tumors 7, 32.
Plain skull films showed a round radiolucent mass with a sclerotic margin. Concomitant lupus with features of scleroderma, castleman disease rheumatology case report. The diagnosis of cmf depends upon its characteristic histological appearance like a lobular pattern with stellateshaped cells in a myxoid or. Jan 02, 2017 on mri, chondromyxoid fibroma shows a multilobulated pattern, with low signal intensity on t1weighted images and high signal intensity on t2weighted images. The differential diagnosis included the chondroblastoma, the aneurysmal cyst and. To describe the mr findings of chondromyxoid fibroma. Males have a higher incidence, with no other demographic bias 3. We describe the cytologic features of chondromyxoid fibroma in fineneedle aspiration biopsy specimens in 4 patients.
Jaffe and lichtenstein first described the condition in 1943. Chondromyxoid fibroma is a rare, benign tumor of bone that represents fewer than 1% of all benign and malignant tumors of bone. To our knowledge, this is the first reportable case of cmp presenting with undifferentiated connective tissue. We present here an unusual case of a chondromyxoid fibroma that occurred in the epiphysis of the proximal tibia with an open growth plate. Chondromyxoid fibroma is a benign, although potentially aggressive tumor, with a cartilagelike matrix, accounting for approximately 1% of all bone tumors. The most commonly affected area is the metaphysial region of the proximal tibia and the distal femur 2. Tumors located in the distal extremities such as the hands or feet may only present clinically with signs of painless swelling 5. The decisive role played by the radiologist in identifying the benign nature of the lesion is emphasized.
Most cases are characterised by grm1 gene fusion or promoter swapping. Activating rearrangements of grm1 metabotropic glutamate receptor 1. Most chondromyxoid fibromas are small 1 to 4 cm, round or ovalshaped tumors. The treatment of the second ary abc is based on the appropriate treatment for the underlying tumor. A 35yearold man visited us with a chief complaint of painful swelling of the finger. A rare case of epiphyseal chondromyxoid fibroma of the. An adult male patient at the age of 28 suffered a fracture of the lateral malleolus due to an eccentric, lytic, lobular lesion in the epiphysis, during a basketball match. Chondromyxoid fibromas are rare, benign tumours that consist of immature myxoid mesenchymal tissue with features of primitive cartilaginous differentiation. Chondromyxoid fibroma cmf is one of the rarest benign tumors of cartilaginous origin. An additional peak of incidence has been observed between 50 and 70 years of age. The treatment of the secondary abc is based on the appropriate treatment for the underlying tumor. It is a benign noncancerous tumor that most often develops in older children and young adults under 30 years of age. Chondromyxoid fibroma with secondary aneurysmal bone cyst in.
Radiological evaluation of a chondromyxoid fibroma published. Huge chondromyxoid fibroma of the right iliac wing with. Huge chondromyxoid fibroma of the right iliac wing with tremendous soft tissue extensions hosameldeen mostafa ali, md department of radiology, benha university, benha, egypt address correspondence to. It is associated with high local recurrence rates with a small risk chondromyxoid matrix in a distinctive histological pattern. Radiographic and histologic patterns of calcification in chondromyxoid fibroma. Chondromyxoid fibromas are rare, benign tumours that resemble cartilage, initially arising in the cortex of affected bones most commonly the lower limbsy their documented incidence is less than 1 % of all primary bone tumours approximately 2% of all benign bone tumours with males and females being equally affectedy. Chondromyxoid fibroma is an uncommon benign cartilaginous tumor of the bone. Chondromyxoid fibroma of bone, with emphasis on its morphological relationship to benign chondroblastoma. A 40yearold female presented a progressively enlarging mass of her anterior chest wall. Complete local excision with tumorfree margins avoids the recurrence of cmf, the underlying tumor in this case report. We analyzed rapid romanowsky and papanicolaoustained slides with a respect to overall cellularity, the presence of hypercellular chondromyxoid fragments hcfs, nuclear atypia, cytoplasmic features, and the presence of giant cells. Chondromyxoid fibromas cmfs are extremely rare, benign cartilaginous neoplasms that account for benign bone tumor arising in young adults.
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